Announcement original work dissertation



List of Announcement of Fiscal Year 2006

○ Result of research of Fiscal Year 2006

Computations of Molecular Interactions and Reactivity group
(Members: AIDA, Misako; IWATA, Suehiro; MATSUBARA, Toshiaki; SAKAE, Yoshitake; HARADA, Takanori)


Masato Tanaka and Misako Aida, “Ab initio MO and quasi-classical direct ab initio MD studies on the nitrogen inversion of trimethylamine,” Chemical Physics Letters, 417, 316-319 (2006).

Nobuyuki Akai, Takanori Harada, Kei Shin-ya, Keiichi Ohno and Misako Aida, “Photoinduced amino?imino tautomerism: An infrared study of 2-amino-5-methylpyridine in a low-temperature argon matrix,” Journal of Physical Chemistry A, 110, 6016-6022 (2006).

Nobuyuki Akai, Keiichi Ohno and Misako Aida, “Photochemistry of 2-(methylamino)pyridine in a low-temperature argon matrix: Amino-imino tautomerism and rotational isomerism,” Journal of Photochemistry and Photobiology. A, 187, 113-118 (2007).

Adchara Padermshoke, Yukiteru Katsumoto and Misako Aida, “Dimerization and Double Proton Transfer-Induced Tautomerism of 4(3H)-Pyrimidinone in Solution Studied by IR Spectroscopy and Quantum Chemical Calculations,” Journal of Physical Chemistry B, 110, 26388-26395 (2006).

Toshiko Miyake and Misako Aida, “H-bond patterns and structure distributions of water octamer (H2O)8 at finite temperatures,” Chem. Phys. Lett. 427, 215-220 (2006).

Tomoki Yoshida and Misako Aida, “BSSE-corrected Three-body Interaction Energy in the Recognition of GC Base Pair by Asparagine, Chemistry Letters,” 36(1), 124-125 (2007).

Tomoki Yoshida and Misako Aida, “Population of 6-Enol Form is Higher in 8-Oxoguanine than in Guanine,” Chemistry Letters, 35(8), 924-925 (2006).

Suehiro Iwata, “Locally projected molecular orbital theory for molecular interaction with a high-spin open shell molecule,” Journal of Theoretical and Computational Chemistry, 5, 819-833 (2006).

Suehiro Iwata and Takeshi Nagata, “Perturbation expansion theory corrected from basis set superposition error II. Charge-transfer, pair correlation and dispersion terms,” Theoretical Chemistry Accounts, 117, 137-147 (2007).

Valerie Rodriguez-Garcia, Kiyoshi Yagi, Kimihiko Hirao, Suehiro Iwata and So Hirata, “Franck?Condon factors based on anharmonic vibrational wave functions of polyatomic molecules,” Journal of Chemical Physics, 125, 014109 (2006).

Suehiro Iwata, “The Single Excitation Perturbation Expansion Theory Based on the Locally Projected Molecular Orbitals for Molecular Interaction:Comparison with the Counterpoise Corrected Energy,” Chemical Physics Letters, 431, 204-209 (2006).

Toshiaki. Matsubara, Michel Dupuis and Misako Aida, “The ONIOM molecular dynamics method for biochemical applications: cytidine deaminase,” Chemical Physics Letters, 437(1-3), 138-142 (2007).

Eiji Shirakawa, Kouji Nakayama, Ryotaro Morita, Teruhisa Tsuchimoto, Yusuke Kawakami and Toshiaki Matsubara, “Ruthenium-Catalyzed Addition of Alkynes to Alkynylstannanes with Migration of the Stannyl Group,” Bulletin of the Chemical Society of Japan, 79, 1963-1976 (2006).

Toshiaki Matsubara, Masashi Ishikura and Misako Aida, “A Quantum Chemical Study of the Catalysis for Cytidine Deaminase: Contribution of the extra water molecule,” Journal of Chemical Information and Modeling, 46, 1276-1285 (2006).

Shaheda A. Wahab, Takanori Harada, Toshiaki Matsubara and Misako Aida, “Quantum Chemical Study of the Interaction of the Short-Chain Poly(oxyethylene)s CH3(OCH2CH2)mOCH3 (C1EmC1; m=1 and 2) with a Water Molecule in the Gas Phase and the Solutions,” Journal of Physical Chemistry A, 110 (3), 1052-1059 (2006).

Structural design, Predict and Synthesis group
(Members: INOUE, Katsuya; EBATA, Takayuki; ISHIBASHI, Taka-aki; KOJIMA, Satoshi)
(Postdoctoral:AKAI, Nobuyuki; NAGAHARA, Tetsuhiko)


Satoshi Kojima, Kouji Fujitomo, Yoshiaki Itoh, Kyoko Hiroike, Masaaki Murakami and Katsuo Ohkata, “The Effect of Substituents on the Pyridine Ring in the Diastereoselective Cyclopropanation Reaction of Pyridinium Ylides Bearing an 8-Phenylmenthyl Ester Group,” Heterocycles, 68(2), 679-694 (2006).

Satoshi Kojima, Kazumasa Kajiyama, Masaaki Nakamoto, Shiro Matsukawa and Kin-ya Akiba, “The ligand-exchange process of P-Hapical phosphoranes and the thermal formation and pseudorotation of anti-apicophilic spirophosphoranes,” European Journal of Organic Chemistry, 2006(1), 218-234.

Satoshi Kojima, Kouji Fujitomo, Yoshiaki Itoh, Kyoko Hiroike, Masaaki Murakami and Katsuo Ohkata, “The Effect of Substituents on the Pyridine Ring in the Diastereoselective Cyclopropanation Reaction of Pyridinium Ylides Bearing an 8-Phenylmenthyl Ester Group,” Heterocycles, 68(2), 679-694 (2006).

Satoshi Kojima, Kazumasa Kajiyama, Masaaki Nakamoto, Shiro Matsukawa and Kin-ya Akiba, “The ligand-exchange process of P-Hapical phosphoranes and the thermal formation and pseudorotation of anti-apicophilic spirophosphoranes,” European Journal of Organic Chemistry, (1), 218-234 (2006).

Kazumasa Kajiyama, M. Yoshimune, Satoshi Kojima, and Kin-ya Akiba, “A New Method for the Formation of Anti-Apicophilic (O-cis) Spirophosphoranes. Kinetic Studies on the Stereomutation of O-cis Arylphosphoranes to Their O-trans Isomers,” European Journal of Organic Chemistry, (12), 2739-2746 (2006).

Takahiro Adachi, Shiro Matsukawa, Masaaki Nakamoto, Kazumasa Kajiyama, Satoshi Kojima, Yohsuke Yamamoto, Kin-ya Akiba, Suyong Re, and Shigeru Nagase, “Experimental Determination of nN??*P-O Interaction Energy of O-Equatorial C-Apical Phosphoranes Bearing a Primary Amino Group,” Inorganic Chemistry, 45(18), 7269-7277 (2006).

Satoshi Kojima, Maki Suzuki, Akito Watanabe, and Katsuo Ohkata “Asymmetric Synthesis of Activated Cyclopropanes Catalyzed by Cinchonidine as a Chiral Bronsted Base,” Tetrahedron Letters, 47(51), 9061-9065 (2006).

Xin-Dong Jiang, Ken-ichiro Kakuda, Shiro Matsukawa, Hideaki Yamamichi, Satoshi Kojima, and Yohsuke Yamamoto “Synthesis and Application of a Bidentate Ligand Based on Decafluoro-3-phenyl-3-pentanol: Steric Effect of Pentafluoroethyl Groups on the Stereomutation of O-Equatorial C-Apical Spirophosphoranes,” Chemistry an Asian Journal, 2(2), 314-323 (2007).

Kazuhisa Tanabe, Ayako Fujie, Naoki Ohmori, Yoshikazu Hiraga, Satoshi Kojima and Katsuo Ohkata, “Studies on Ring-Closing Metathesis for the 11-Membered Ring System for the Synthesis of Daphnezomine C,” Bulletin of the Chemical Society of Japan, in press (2007).

Bin Zhang, Zheming Wang, Yan Zhang, Kazuyuki Takahashi, Yoshinori Okano, Hengbo Cui, Hayao Kobayashi, Katsuya Inoue, Mohamedally Kurmoo, Francis L. Pratt and Daoben Zhu, “Hybrid Organic-Inorganic Conductor with a Magnetic Chain Anion: K-BETS2[Fe III -(C2O4)Cl2] [BETS ] Bis(ethylenedithio)tet-raselenafulvalene],” Inorganic Chemistry, 45, 3275-3280 (2006).

Kazuki Ohishi, Wataru Higemoto, Akihiro Koda, Shanta R. Saha, Ryosuke Kadono, Katsuya Inoue, Hiroyuki Imai, Hiroyuki Higashikawa, “Possible Magnetic Chirality in Optically Chiral Magnet [Cr(CN)6][Mn(S)-pnH(H2O)](H2O) Probed by Muon Spin Rotation and Relaxation,” Journal of the Physical Society of Japan, 75(6), 63705 (2006). Editor's Choice

Shinya Hayami, Natsuko Motokawa, Aya Shuto, Naoji Masuhara, Yasuhiro Umebayashi, Yonezo Maeda, Osamu Sato, Katsuya Inoue, Ryo Kawajiri, Yui Kumura, Takashi Okubo and Tadaoki Mitani, “Hysteresis Loops in Dielectric Properties of the Thermochromic Copper(II)Compounds,” Chemistry Letters, 35, 1114-1115 (2006).

Takaki Morita, Satoru Nakashima, Koji Yamada, Katsuya Inoue, “Occurrence of the Spin-crossover Phenomenon of Assembled Complexes, Fe(NCX)2(bpa)2(X=S, BH3; bpa=1,2-Bis(4-pyridyl)ethane) by Enclathrating Organic Guest Molecule,” Chemistry Letters, 35, 1042-1043 (2006).

S. Ovchinnikov, I. G. Bostrem, V. E. Sinitsyn, A. S. Boyarchenkov and N. V. Baranov, K. Inoue, “Quantum dissipation theory of slow magnetic relaxation mediated by domain-wall motion in the one-dimensional chain compound [Mn(hfac)2BNOH],” Physical Review B, 74, 174427 (2006).

R. B. Morgunov, V. L. Berdinskia, M. V. Kirman, K. Inoue, J. Kishine, Y. Yoshida and Y. Tanimoto, “Spin Solitons in Molecular Magnetic Materials with the Chiral Structure,” JETP Letters, 848, 446-450 (2006).

Y Fujiwara, Y Katsumoto, Y Ohishi, M Koyama, K. Ohno, M Akita, KInoue and Y Tanimoto, “Polymerization of N-isopropylacrylamide under magnetic levitation,” Journal of Physics: Conference Series, 51, 458-461 (2006).

T. Kanzawa, Y. Hosokoshi, K. Katoh, S. Nishihara, K. Inoue and H. Nojiri, “EPR measurements of a two-dimensional spin frustrated system, BIPNNBNO with S=1 and S=1/2,” Journal of Physics: Conference Series, 51, 91-94 (2006).

Shinya Hayami, Soushi Miyazaki, Masahiko Yamamoto, Kenji Hiki, Natsuko Motokawa, Aya Shuto, Katsuya Inoue, Teruo Shinmyozu, Yonezo Maeda, “Spin-crossover behaviors of iron(III) compounds with strong intermolecular interactions,” Bulletin of the Chemical Society of Japan, 79, 442-450 (2006).

Satoru Fujiyoshi, Taka-aki Ishibashi and Hiroshi Onishi, “Molecular Vibrations at A Liquid-Liquid Interface Observed by Fourth-Order Raman Spectroscopy,” Journal of Physical Chemistry B, 110, 9571-9578 (2006).

Kan Takeshita, Akira Yamakata, Taka-aki Ishibashi, Hiroshi Onishi, Kazumoto Nishijima, Teruhisa Ohno, “Transient IR Absorption Study of Charge Carriers Photogenerated in Sulfur-doped TiO2,” Journal of Photochemistry and Photobiology A: Chemistry, 177, 269-275 (2006).

N. Tsuji, S. Ishiuchi, M. Sakai, M. Fujii, T. Ebata, C. Jouvet, C. Dedonder-Lardeux, “Excited State Hydrogen Transfer in Fluorophenol Ammonia Clusters Studied by Two-Color REMPI Spectroscopy,” Phys. Chem. Chem. Phys., 8, 114-121 (2006).

K. Kouyama, M. Miyazaki, N. Mikami and T. Ebata, “IR laser manipulation of cis-trans isomerization of 2-naphthol and its hydrogen-bonded clusters,” Journal of Chemical Physics, 124, 054315 (2006).

T. Hashimoto, Y. Takasu, Y. Yamada and T. Ebata, “Anomalous conformer dependent S1 lifetime of L-Phenylalanine,” Chem. Phys. Lett., 421, 227-231 (2006).

Y. Yamada, M. Kayano, N. Mikami and T. Ebata, “Picosecond IR-UV pump-probe study on the vibrational relaxation of phenol-ethylene hydrogen-bonded cluster -Difference of relaxation route/rate between the donor and the acceptor site excitations,” Journal of Physical Chemistry A, 110, 6250-6255 (2006).

T. Ebata, T. Hashimoto, T. Ito, Y. Inokuchi, F. Altunsu, B. Brutschy and P. Tarakeshwar, “Hydration Profiles of Aromatic Amino Acids: Conformations and Vibrations of L-Phenylalanine-(H2O)n Clusters,” (cover picture), Phys. Chem. Chem. Phys., 8, 4783-4791 (2006).

Y. Yamada, J. Okano, N. Mikami and T. Ebata, “Picosecond time-resolved study on the intramolecular vibrational energy redistribution of NH stretching vibration of jet-cooled aniline and its isotopomer,” Chem. Phys. Lett., 432, 421-425 (2006).


Protein Informatics group
(Members: IDE, Hiroshi; IZUMI, Shunsuke; KATAYANAGI, Katsuo)
(Postdoctoral:YAMAMOTO, Tatsuya)


Masahiro Iwakura, Kosuke Maki, Hisashi Takahashi, Tatsuyuki Takenawa, Akiko Yokota, Katsuo Katayanagi, Tadashi Kamiyama and Kunihiko Gekko, “Evolution design of a hyper-active cysteine-and methionine-free mutant of Escherichia coli dehydrofolate reductase,” Journal of Biological Chemistry, in press (2006).

E. Matsuo, C. Toda, M. Watanabe, N. Ojima, S. Izumi, K. Tanaka and O. Nishimura, “Selective Detection of NBS-Labeled Peptides Using Specific Matrix and MALDI-TOF Mass Spectrometer,” Proteomics, 6, 2042 (2006).

Shuichi Nishikubo, Masaru Ohara, Masae Ikura, Katsuo Katayanagi, Tamaki Fujiwara, Hitoshi Komatsuzawa, Hidemi Kurihara, and Motoyuki Sugai, “Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans,” Infection and Immunity, 74, 7014-7020 (2006).

Masahiro Iwakura, Kosuke Maki, Hisashi Takahashi, Tatsuyuki Takenawa, Akiko Yokota, Katsuo Katayanagi, Tadashi Kamiyama, and Kunihiko Gekko, “Evolution design of a hyper-active cysteine-and methionine-free mutant of Escherichia coli dehydrofolate reductase,” Journal of Biological Chemistry, 281 13234-13246 (2006).

Manabu Kurayoshi, Hideki Yamamoto, Shunsuke Izumi and Akira Kikuchi, “Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signaling,” Biochemical Journal, 402(3), 515-523 (2007).

Koji Ohashi, Takeshi Yamazaki, Shigeyuki Kitamura, Shigeru Ohta, Shunsuke Izumi and Shiro Kominami, “Allosteric inhibition of rat neuronal nitric-oxide synthase caused by interference with the binding of calmodulin to the enzyme,” Biochimica et Biophysica Acta, General Subjects, 1770(2), 231-240 (2007).

Takeshi Yamazaki, Chisa Matsuoka, Miho Gendou, Shunsuke Izumi, Dong Zhao, Irina Artemenko, Colin R. Jefcoate, Shiro Kominami, “Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein,” Biochimica Biophysica Acta, Proteins and Proteomics, 1764(10), 1561-1567 (2006).

Isamu Aiba, Tomoaki Yamasaki, Toshimasa Shinki, Shunsuke Izumi, Keiko Yamamoto, Sachiko Yamada, Hiroaki Terato, Hiroshi Ide, Yoshihiko Ohyama, “Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases,” Steroids, 71(10), 849-856 (2006).

Tomoko Yokoyama, Ken Yamane, Atsushi Minamoto, Hidetoshi Tsukamoto, Hidetoshi Yamashita, Shunsuke Izumi, George Hoppe, Jonathan E. Sears, Hiromu K. Mishima, “High glucose concentration induces elevated expression of anti-oxidant and proteolytic enzymes in cultured human retinal pigment epithelial cells,” Experimental Eye Research, 83(3), 602-609 (2006).

Tatsuya Yamamoto, Shunsuke Izumi, Kunihiko Gekko, “Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E. coli.” FEBS Letters, 580(15), 3638-3642 (2006).

Laleh Nikfarjam, Shunsuke Izumi, Takeshi Yamazaki, Shiro Kominami, “The interaction of cytochrome P450 17a with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry,” Biochimica et Biophysica Acta, Proteins and Proteomics, 1764(6), 1126-1131 (2006).

Biological system Informatics group
(Members : TANAKA, Nobukazu; OZAWA, Koichiro; KOTAKE, Yaichirou; KATSUMOTO, Yukiteru)
(Postdoctoral : Adchara Padermshoke)
(Visiting Professor : SAITO, Hazime)


Yusuke Nakatsu, Yaichiro Kotake, Kazuya Komasaka, Hiroko Hakozaki, Ryota Taguchi, Toshiaki Kume, Akinori Akaike and Shigeru Ohta, “Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons,” Toxicological Sciences, 89, 235-242 (2006).

Yusuke Nakatsu, Yaihchiro Kotake and Shigeru Ohta, “Tributyltin-induced cell death is meadiated by calpain in PC12 cells,” Neurotoxicology in press.

Kazutoshi Yamamoto, Satoru Tuzi, Hazime Saito, Izuru Kawamura, Akira Naito, “Conformation and Dynamics Changes of Bacteriorhodopsin and Its D85N Mutant in the Absence of 2D crystalline Lattice as Revealed by Site-directed 13C NMR”, Biochimica et Biophysica Acta, 1758, 181-189 (2006).

Miya Kamihira, Hazime Saito and Akira Naito, “Kinetics of amyloid fibril formation of human calcitonin”, In “Modern Magnetic Resonance”, 1, ed. By Graham A. Webb, Springer, 3-9, 2006.

Hazime Saito, “Site-directed NMR Studies on Membrane Proteins”, In “Modern Magnetic Resonance”, 1, ed. By Graham A. Webb, Springer, pp. 283-289, (2006).

Keiichi Ohno, Hiroshi Takao and Yukiteru Katsumoto, “Geometrical behavior of hydrogen bonding patterns in the a-dodecyl-w-hydroxy- tris(oxyethylene)-water system monitored by near infrared spectroscopy,” Spectrochim. Acta, Part A, 63(3), 690-693 (2006).

Kanae Hyoda, Toru Hosoi, Naohiro Horie, Yasunobu Okuma, Koichiro Ozawa, Yasuyuki Nomura, “PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells,” Biochemical and Biophysical Research Communications, 340, 286-290 (2006).

Toru Hosoi, Chie Hashimoto, Michiko Yoshii, Yasunobu Okuma, Yasuyuki Nomura, Koichiro Ozawa, “Mechanisms of endoplasmic reticulum stress-induced leptin resistant,” Journal of Pharmacological Sciences, 100, 244P (2006).

Koichiro Ozawa, Toru Hosoi, Fumie Onishi, Michiko Yoshii, “Inhibitory effect of purine derivatives on histamine release in RBL-2H3 cells,” Journal of Pharmacological Sciences, 100, 285P (2006).

遠藤 万里子,知念 聖子,吉井 美智子,石原 熊寿,太刀掛 稔,小澤 孝一郎,「注射薬配合変化予測システムの構築と活用」広島県病院薬剤師会誌, 39(3), 3-6 (2004);優秀論文賞

遠藤 万里子,太刀掛 稔,吉井 美智子,小澤 孝一郎,“PC (personal Computer) を用いた注射剤配合変化予測システムの構築と活用”(Construction and Practical Use of Injection Incompatibirity Prediction System)共済医報, 54(4), 331-335 (2005).優秀論文賞

A. Tamura, K. Ozawa, T. Ohya, N. Tsuyama, EM Eyring and T. Masujuma, “Nanokinetics of drug molecule transport into a single cell,” Nanomedicine, 1, 345-350 (2006).

金森 久幸,有田 健一,星野 響,大久保 雅通,小澤 孝一郎,神田 博史,宗 文彦,田坂佳千,田中 秀雄,村上 行雄,黐池 千恵子,森井 紀夫,山崎 健次,行武 理江,木平 健治,“広島県民の健康食品に関する意識調査”広島医学, 59, 602-611 (2006).

Toru Hosoi, Kanae Hyoda, Yasunobu Okuma, Yasuyuki Nomura and Koichiro Ozawa, “Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression,” European Journal of Pharmacology, 554, 8-11 (2007).

Toru Hosoi, Kanae Hyoda, Yasunobu Okuma, Yasuyuki Nomura and Koichiro Ozawa, “Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease,” Cell Research, 17, 184-186 (2007).

甲〆 慎二,鮫島 美穂,三島 純子,泉 由香,河田 邦貴,西島 宏明,泉 憲政,小澤 光一郎,“乳幼児の散剤の服用についてーコンプライアンス向上への取り組みとその成果?,”小児科臨床60, 337-349 (2007).

Toru Hosoi, Naomi Matsunami, Tomoko Nagahama, Yasunobu Okuma, Koichiro Ozawa, Tsuyoshi Takizawa and Yasuyuki Nomura, “2-Aminopurine inhibits leptin receptor signal transduction,” Europian Journal of Pharmacology, 553, 61-66 (2006).

Toru Hosoi, Kanae Hyoda, Yasunobu Okuma, Yasuyuki Nomura and Koichiro Ozawa, “Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression,” Europian Journal of Pharmacology, 554, 8-11 (2007).

Toru Hosoi, Chie Hashimoto, Michiko Yoshii, Tsuyoshi Miyahara, Koichiro Ozawa, “Effect of endplasmic reticulum stress on leptin signal transduction,” Journal of Pharmacological Sciences, 103, 53 (2007).

Noritaka Sugiyama, Toru Hosoi, Hisashi Kodama, Hitomi Kawada, Koichiro Ozawa, “Inhibitory effect of adenosine on leptin-induced STAT3 phosphorylation,” Journal of Pharmacological Sciences, 103, 175 (2007).

Ayaka Kume, Toru Hosoi, Atushi Saito, Yasunobu Okuma, Yasuyuki Nomura, Koichiro Ozawa, “Amiloride hydrochloride inhibited endoplasmic reticulum stress responses,” Journal of Pharmacological Sciences, 103, 182 (2007)

Toru Hosoi, Kanae Hyoda, Yasunobu Okuma, Yasuyuki Nomura and Koichiro Ozawa, “Akt up- and down-regulation in response to endoplasmic reticulum stress,” Brain Research, in press (2007)

Yusuke Nakatsu, Yaichiro Kotake, Kazuya Komasaka, Hiroko Hakozaki, Ryota Taguchi, Toshiaki Kume, Akinori Akaike and Shigeru Ohta, “Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons,” Toxicological Sciences, 89, 235-242 (2006).

Yusuke Nakatsu, Yaihchiro Kotake and Shigeru Ohta, “Tributyltin-induced cell death is meadiated by calpain in PC12 cells,” Neurotoxicology, 27, 587-593 (2006).

Katsuhiro Okuda, Yaichiro Kotake and Shigeru Ohta, “Parkinsonism-preventing activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo,” Biological Pharmaceutical Bulletin, 29, 1401-1403 (2006).

Yaichiro Kotake, Yoko Sekiya, Katsuhiro Okuda and Shigeru Ohta, “Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition,” Neurotoxicology, 28, 27-32 (2007).

Yusuke Nakatsu, Yaichiro Kotake and Shigeru Ohta, “Concentration dependence of the mechanisms of tributyltin-induced apoptosis,” Toxicological Sciences, in press.

R. E. A. Moghaieb, N. Tanaka, H. Saneoka, Y. Murooka, H. Ono, H. Morikawa, A. Nakamura, N. T. Nguyen, R. Suwa and K. Fujita, Characterization of salt tolerance in ectoine-transformed tobacco plants (Nicotiana tabacum): photosynthesis, osmotic adjustment, and nitrogen partitioning,” Plant, Cell & Environment, 29, 173-182 (2006).

Dominique Caparros-Lefebvre, John Steele, Yaichiro Kotake and Shigeru Ohta, “Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: possible synergy of neurotoxins,” Movement Disorders, 21, 1769-1771 (2006).

Yaichiro Kotake, “Neurotoxicity induced by environmental low-molecular-weight substances”, Journal of Health Science, 53, 639-643 (2007).

Calculator and Information group
(Members: KAMINUMA, Tsuguchika; ISHINO, Yoko; MORIMOTO, Yasuhiko; OHKURA, Kazuhiro)

Yoko Ishino, Yan Jin, “An Information Value Based Approach to Design Procedure Capture,” Advanced Engineering Informatics, 20 (1), 89-107 (2006).






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